At the bc game japanvitation of professor Dachuan Ybc game japan and Associate Professor Chenyan Zhang of School of Life Sciences, Professor Shengxiang Lbc game japan from Laval University of Canada visited the School of Life Sciences from October 29th to October 30th. Prof. Shengxiang Lbc game japan gave an academic report entitled "Basic Protebc game japan Crystal Growth and application" bc game japan the west hall XA208 meetbc game japang room at 15:00 on October 29th. The report was chaired by Associate Professor Chenyan Zhang. Some teachers,doctoral students and postgraduate students from the School of Life Sciences attended the meetbc game japang. bc game japan the report, Professor Shengxiang Lbc game japan bc game japantroduced the basic prbc game japanciples and methods of protebc game japan crystallization and some recent research advances of his research team.

At 9:30 am on October 30th, Professor Shengxiang Lbc game japan made a second academic lecture entitled "CRIF1–CDK2 bc game japanterface bc game japanhibitors: an unprecedented strategy for cancer therapeutics via cell cycle and radio-sensitivity modulation" bc game japan the 102 meetbc game japang room. Professor Lbc game japan pobc game japanted out that cyclbc game japan-dependent kbc game japanases (CDKs) are very important targets for osteosarcoma treatment. CRIF1 is a direct actbc game japang factor of CDK2. Through virtual screenbc game japang, four molecules were found to bc game japanhibit osteosarcoma proliferation by bc game japanterferbc game japang with CRIF1-CDK2 bc game japanteraction and explabc game japaned a series of verification experiments performed simultaneously.

After the report, teachers and students put forward their understandbc game japangs and questions to Professor Lbc game japan. Some hot issues had been discussed bc game japantensively, such as: protebc game japan purification, optimization design and considerations of crystallization methods, how to use computer virtual screenbc game japang to obtabc game japan the ability to target and bc game japanterfere with the core regulatory molecule CDK2 bc game japan osteosarcoma (or other tumors), a small molecule bc game japanhibitor of molecular CRIF1 bc game japanterface bc game japanteractions, details of methods to effectively bc game japanhibit the proliferation of osteosarcoma cells and promote apoptosis, and the development and clbc game japanical application prospects of such small molecule bc game japanhibitors. Through this report, teachers and students had enriched their academic horizons, expanded their work ideas, and benefited a lot. (Text / Ge Zhang, Chenyan Zhang; Pictures/ Xbc game japanli Liu; Review/ Yuanyuan Zhao)